Anti-inflammatory, analgesic, and anti-arthritic for use exclusively in sport horses.
Phenylbutazone is a non-steroidal anti-inflammatory drug (NSAID) that is highly absorbed from the gastrointestinal tract. It inhibits the arachidonic acid cascade, reducing inflammation, edema, erythema, and pain. When administered on an empty stomach, it reaches peak blood concentration sooner than when given with feed (hay and/or grains).
It is eliminated in the bile after being metabolized in the liver; only 2% is excreted in the urine.

Indications for use

It is especially indicated for the treatment of acute and chronic inflammatory processes, as well as for suppressing the pain response in musculoskeletal disorders.

Via of Administration and Dosage

Dosage: 4.4 mg/kg body weight. This is equivalent to 2.2 g of phenylbutazone in a 500 kg animal or 0.44 g of phenylbutazone per 100 kg body weight.
For a 500 kg animal, this corresponds to 11.28 g of oral paste.
Frequency of administration: Every 12 or 24 hours.
Route of administration: Oral.
Duration of treatment: For 3 to 5 days, at the discretion of the attending veterinarian, depending on the animal's progress.

Contraindications

Do not use in conjunction with warfarin, sulfonamides, or nephrotoxic drugs (aminoglycoside antibiotics, etc.).
Do not use if digestive ulcers, coagulation defects, cardiac, renal, or hepatic dysfunction are suspected, or if thyroid conditions or drug allergies are present.

Warnings

Do not exceed the stated dosage.
Keep out of reach of children.
May cause hypersensitivity in susceptible individuals. Use with caution in ponies or foals, geriatric animals, or animals with renal, hepatic, or hypovolemic conditions.
Discontinue use if ulcers appear in the oral, gastric, or intestinal mucosa, or if the feces become dark or tarry.
Do not administer with feed, as it delays absorption. In case of accidental ingestion, seek medical attention and take the product label with you.
Do not administer to horses intended for human consumption.
Store in a cool, dry place between 15 and 25°C.
For veterinary use.

Formula

• Phenylbutazone19,5 g
• Formulation agents q.s 100 g

Presentation

34 g siringe.

Cortivet Depot Action® is a long-acting anti-inflammatory composed of two different dexamethasone salts: dexamethasone phosphate and dexamethasone acetate.
While dexamethasone phosphate is a rapidly released and metabolized corticosteroid, dexamethasone acetate is a depot glucocorticoid, with its release occurring between 2 and 14 days after application. The combination of these compounds has virtually no mineralocorticoid activity, making this product a very useful therapeutic tool for both acute and chronic inflammatory processes.

INDICATIONS FOR USE

It is indicated for shock, stress, Neonatal Dysfunction Syndrome, traumatic brain injury, spinal cord compression, bronchospasm, allergic reactions, autoimmune syndromes, dermatitis and inflammation of the musculoskeletal system, and arthritis of traumatic origin via intra-articular injection.

VIA OF ADMINISTRATION AND DOSAGE

Dosage: Horses of all ages: 1 to 4 ml per 100 kg body weight (0.05 to 0.2 mg/kg body weight).
Frequency of Administration: The treatment is a single application. Repeat administration is at the discretion of the attending veterinarian.
For intra-articular applications, the dosage will depend on the desired effect and the capacity of the joint being treated.
Route of Administration: Cortivet Depot Action® is a sterile injectable suspension and can be administered intramuscularly, subcutaneously, intra-articularly, epidurally, or by local infiltration.

CONTRAINDICATIONS

Do not administer to immunosuppressed animals, concurrently with any vaccine, or in cases of fungal, viral, or bacterial infections where appropriate antibiotic therapy has not been initiated.
Do not use when gastric ulcer is suspected.
Do not administer intrasynovially if sepsis is observed in or around the joint, if there is a possibility of bone fracture or damaged cartilage, or if degenerative bone lesions or osteochondrosis are present.

WARNINGS

Store between 15 and 25°C in a dry, hygienic place, away from direct sunlight. Keep out of reach of children.
For veterinary use only.

Formula

• Dexamethasone 21 sodium phosphate 25 mg
• Dexamethasone acetate 25 mg
• Formulation agents q.s. 10 ml

PRESENTATION

10 ml Vial. Sterile solution.

Dexamethasone 21-phosphate is a second-generation fluorinated corticosteroid with a very rapid onset of action. It reduces the inflammatory response by inhibiting prostaglandin synthesis, stabilizing lysosomal membranes, reducing enzyme release, and inhibiting the migration of inflammatory cells (neutrophils and monocytes/macrophages). It also decreases the ability of basophils and mast cells to release histamine. Furthermore, it reduces the release of toxic oxygen metabolites and inhibits the synthesis and secretion of chemotaxis (interleukin I). These properties make it the drug of choice for all acute inflammatory processes, whether or not they are life-threatening.
Because more than 80% of the drug circulates bound to plasma proteins, a reduction in these proteins, primarily transcortin, increases susceptibility to the effects of glucocorticoids. It has a direct positive inotropic effect on the heart and in the vessels, increasing reactivity to catecholamines and inhibiting vascular Nitric Oxide Synthetase (NOS), producing an increase in blood pressure.
In cases of shock, whether of hypovolemic, traumatic, hemorrhagic or anaphylactic origin, the use of this drug is recommended in conjunction with appropriate fluid therapy and the application of epinephrine.

INDICATIONS FOR USE

It is indicated for shock, stress, Neonatal Disruption Syndrome, traumatic brain injury, spinal cord compression, bronchospasm, allergic reactions, and all acute inflammations of the musculoskeletal system.

Via of ADMINISTRATION AND DOSAGE

Dosage: It is recommended to administer 0.5 to 1 mL/50 kg of body weight every 24 hours, for no more than 3 consecutive days.
Route of administration: Although all routes of administration are available, the preferred route is intravenous, as it allows for rapid bioavailability of the drug. The frequency and dosage may be modified at the discretion of the attending physician.

CONTRAINDICATIONS

Do not use in animals suffering from diabetes mellitus, uremic syndrome, chronic nephritis, heart failure, osteoporosis, tuberculosis, acute laminitis, gastrointestinal ulcers, or leptospirosis. Do not use in animals with active viral or fungal diseases. Do not use in animals with bacterial diseases without establishing appropriate antibiotic treatment. Do not use in pregnant or lactating females.

WARNINGS

Store the product in a clean, dry place out of the reach of children, between 15 and 25°C.
For veterinary use only.

Formula

• Dexamethasone 21 sodium phosphate 200 mg
• Formulation agents q.s. . 10 ml

PRESENTATION

10 ml Vial. Sterile solution.

Ketoprofen is a nonsteroidal anti-inflammatory, antipyretic, and analgesic belonging chemically to the class 2 arylpropionic acids of the carboxylic acid group.
It is a cyclooxygenase inhibitor and therefore inhibits prostaglandin synthesis, reducing enzyme release and inhibiting the migration of inflammatory cells such as neutrophils and monocytes/macrophages. It is metabolized in the liver and primarily excreted by the kidneys.

INDICATIONS FOR USE

It is especially indicated for the treatment of acute and chronic inflammatory processes, as well as for suppressing the pain response in musculoskeletal disorders.

Vias of ADMINISTRATION AND DOSAGE

Dosage: 2.2 mg/kg (1 ml/45 kg body weight).
Frequency of administration: Daily. Routes of application: Administered parenterally (IM and IV).
When administered parenterally, it is rapidly and completely absorbed, binding to plasma proteins at a rate greater than 92%. However, it reaches high concentrations at sites of inflammation.
Duration of treatment: 3 to 5 days.

CONTRAINDICATIONS

Its use is contraindicated in horses with kidney disease, blood clotting disorders, gastric ulcers, and liver disease.

WARNINGS

It affects the integrity of the gastric mucosa and decreases platelet aggregation. It interacts with anticoagulants and other NSAIDs and microsomal enzyme inducers (barbiturates).
Store the product in a clean, dry place, out of the reach of children, between 15 and 25°C.
For veterinary use only.

Formula

• Ketoprofen 10 g
• Formulation agents q.s. 100 ml

PRESENTATION

100 ml Vial. Sterile solution.