Ampicillin is a betalactamic antibiotic which belongs to aminopenicillin group and they act very well on gram-negative microorganisms and quite well on gram-positive bacteria.
The combination of sodic and benzathine forms grants the possibility of obtaining a quick action (sodic form) and maintaining it during a longer period (benzathine form) by increasing in this way the interval between doses and so increasing the usefulness of the treatment

Indications for Use

Ampicillin being an antibiotic which acts very well on gram-negative micro-organisms and also quite well on Gram-positive bacteria, is a drug which can be used as the chosen antibiotic for acute septicemias and endotoxic shock, as well as the chosen drug together with Penicillin in urinary infections.
It is also recommended in mixed cavity and organic infections; and infections of genito-urinary and musculo-skeletal (septic arthritis) and respiratory systems. Besides it is important to emphasize its excellent action on clostridiosis. It is effective on Escherichia Coli and some species of Salmonella type when it is given in high doses.

Via of Administration and Dosage

Dosage and frequency of administration: - In adult horses, a dose of 5-20 mg/kg every 12 hours is recommended intramuscularly (2.5-10 ml/100 kg).
- In foals, a dose of 11-22 mg/kg is recommended with the same frequency as for adult animals, administered intramuscularly (5-11 ml/100 kg).
- For intrauterine infusions, a total dose of 3 g dissolved in 250 ml of physiological saline solution is recommended.
Routes of administration: Intramuscular - Subcutaneous - Intrauterine. The frequencies and doses may be modified at the discretion of the attending veterinarian.

Contraindications

Do not administer to animals with known hypersensitivity to beta-lactam antibiotics.
Do not administer concurrently with dextrose saline solutions, as this reduces its effectiveness.
Otherwise, it has no contraindications because it is a drug of very low toxicity. Do not administer to animals with known hypersensitivity to beta-lactam antibiotics.

Warning

Store the unreconstituted product in a clean, dry place, out of the reach of children, between 15°C and 25°C. Once reconstituted, store in a refrigerator and use within 48 hours.
For veterinary use only.

Formula

• Sodium Ampicillin2,5 g
• Benzatinic Ampicillin2,5 g
• Sterile apirogen bi-distilled water 25 ml

Presentation

Ampoule containing sterile lyophilized + solvent.

Although it is recommended to implement antibacterial therapy only after doing an anti-biogram, the therapeutical need may necessarily give rise in many cases to empirical use. In this way, Ampicillin, being an antibiotic which acts very well on gram-negative micro-organism, and also very well on gram-positive bacteria makes it a very suitable antibiotic for this kind of situation.
Ampicillin is a betalactamic antibiotic which belongs to aminopenicillin group that goes through the external layer of gram-negative bacteria. As already mentioned, its range of action not only includes gram-positive, but it is also effective with Escherichia Coli and some species of Salmonella type when it is administrated in high doses.
Although aminopenicillins can be administrated orally due to the fact that they are stable in the acid medium of stomach, ampicillin generally produces diarrhoea because it does not have a high absorption rate, so that we prefer the parental (intravenous) presentation. It has a bioavailability of about 100%.

Indications for Use

It is the chosen antibiotic for acute septicemias and endotoxic shock as well as the chosen drug together with Penicillin for urinary infections. It is also recommended for mixed cavity and organic infections as for infections of genitourinary and musculo-skeletal and respiratory systems. Ampicillin provides an excellent action in subjunctival way on infectious conjunctivitis.

Via of Administration and Dosage

Dosage and frequency of administration: 10 to 20 mg/kg (0.05 - 0.1 ml/kg) is recommended every 6-8 hours.
Routes of administration: Intravenous, intramuscular, subcutaneous, and intrauterine.
The frequency and dosage may be modified at the discretion of the attending veterinarian.

Contraindications

Do not administer to animals with known hypersensitivity to beta-lactam antibiotics. Do not administer concurrently with dextrose saline solutions, as this reduces its effectiveness.

Warning

Store the unreconstituted product in a clean, dry place, out of the reach of children, between 15°C and 25°C. Once reconstituted, store in a refrigerator and use within 48 hours.
For veterinary use only.

Formula

• Sodium Ampicillin5 g
• Sterile apirogen bi-distilled water 25 ml

Presentation

Ampoule containing sterile lyophilized + solvent

It is a betalactamine bactericide antibiotic, which the same as all of this group, inhibit the formation of the bacterial wall and are bactericide while they are being formed.
They generate a weak wall which cannot support the pressure during the cell division stage and so break up causing bacteriolysis. For this reason, this Penicillin is more effective during the stage of logarithmical growth of the bacterial colony. It is excellent against Gram-positive germs, but not against Gram-negative bacteria producers of betalactamase (they have a wall 50 times thicker and betalactamase in the periplasmic space). It can be used individually or combined with other antibiotics such as Gentamicin.
As a conclusion, it is important to realize that rather than high doses of the antibiotic at long intervals, it is convenient to rely on a concentration of the antibiotic in stable form and for a prolonged time for optimum action.

Instructions for Use

It is indicated for animals which are immuno-supressed and immunologically immature (neonate) due to its wide safety margin as well as in septicemias, peritonitis, pneumonic processes, abscesses, musculo-skeleton infections, metritis, tetanus, clostridiosis, actinobacilosis, and actinomycosis. In pneumonia caused by Rhodococcus Equi it is convenient to associate it with Equigenta-Vet, where excellent results are observed. Also, as it is eliminated by renal excretion it is found in high concentrations in urinary tracts making it the proper chosen antibiotic for infections that affect this system.
It is not the chosen drug for meningitis due to the low concentration of the drug in cerebrospinal fluid. On the other hand, it is an innocuous antibiotic for pregnant mares. The application of 1 to 3 days of Penicillin for animals at risk of getting equine adenitis is specially recommended.

Via of Administration and Dosage

Adult horses: 15,000 IU/kg - 20,000 IU/kg; equivalent to 5-7 mL/100 kg of body weight.
Foals: 20,000 IU/kg - 100,000 IU/kg; equivalent to 7-30 mL/100 kg of body weight.
Equine Adenitis: 22,000 IU/kg.
Botulism: 22,000 IU/kg - 44,000 IU/kg.
Administer every 4 to 6 hours for at least 7 days.
Intrauterine infusions: Dissolve the contents of the vial in 250 mL of sterile physiological saline solution and administer.
The routes of administration are intravenous, intramuscular, subcutaneous, and intrauterine.

Contraindications

Do not use in animals with known hypersensitivity to beta-lactam antibiotics.

Warning

Store the unreconstituted product in a clean, dry place, out of reach of children, between 15 and 25°C. Once reconstituted, store in a refrigerator and use within 7 days.
For veterinary use only.

Formula

• Sodium Penicillin G 30.000.000 UI
• Sterile apirogen bi-distilled water 100 ml

Presentation

Ampoule containing sterile lyophilized + solvent.