Dexamethasone 21 Phosphate is a 2nd generation fluorinated corticoid with a very quick action and which reduces the inflammatory response by means of inhibiting the synthesis of prostaglandins, stabilizing the lysosomal membranes, reducing the liberation of enzymes and inhibiting the migration of inflammatory cells (neutrophils and monocytes-macrophages) as well as decreasing the capacity of liberating histamine by basophils and mast cells. It also reduces the liberation of toxic metabolites of oxygen and inhibits the synthesis and secretion of chemotoxins (Interleukin I). These properties make it the chosen drug for all those acute inflammatory processes which might affect or not the life of the animal. Due to the fact that more than 80% of drug circulates joined to plasma proteins, a reduction of the latter, basically transcortin, increases the sensibility to the glucocorticoids effects. It has an inotropic positive effect directly on the heart and in the blood vessels it increases the reactivity to the catecholamines and inhibits the vascular Nitric Oxide Synthase (NOS), producing an increase in blood pressure. In cases of shock of hypovolemic, traumatic, haemorrhagic or septic origin, the use of this drug is recommended associated with the corresponding fluid therapy and with the application of epinephrine.

Indications for Use

It is indicated for shock, stress, neonatal maladjustment syndrome, head injuries, medullary compressions, bronchospasm, and allergic reactions and for all those acute inflammations of the locomotive system.

Via of Administration and Dosage

Although all vias of administration are available, the via of choice is intravenous because it allows a quick bio availability of the drug. Recommended to be administered in doses from 0.2 to 0.8 mg/kg of weight and 2 mg/kg of weight in shock cases. In this last case, repeat 3 and 6 hours later.

Contraindications

In cases where there is a suspected circulatory disorder at capillary circulation level do not use or use under a strict control because it encourages thrombotic processes.

Warning

Keep the product in a clean, dry place between 4º and 30ºC and out of children's reach.
Veterinary use.

Presentation

Ampoule of 10 ml of sterile injectable solution.

Formula

• Dexamethasone 21 Phosphate 200 g
• Formula Agents c.s.p. 10 ml

The association of these Dexamethasones hardly contains any mineral corticoid but have the same anti-inflammatory properties as any other corticoid, and make this medicine a useful therapeutic tool in acute and chronic inflammatory processes due to the different vehicles which accompany the Dexamethasone, which allow it to exert its action in both inflammatory stages. The acetate form of Dexamethasone is effective from 4 to 14 days.
It is important to mention that the use of corticoid by intra-articular form is controversial since there is evidence that high doses or applications over a long period can damage the articular cartilage. However, the vehicle used in this product causes the systemic absorption to be very low when applied judiciously. It can prevent the retraction of wounds caused by surgery or injury as it delays scar formation.

Indications for Use

It is indicated for shock, stress, neonatal maladjustment syndrome, head injuries, medullary compressions, bronchospasms, allergic reactions, autoimmune syndromes, dermatitis and inflammations of the locomotive system and in arthritis caused through injury by intra-articular via.

Via of Administration and Dosage

Although all the vias of administration are available, the chosen via is the intravenous, the intramuscular or the intra-articular, depending on the pathology to be treated and the seriousness of the symptoms. It is advisable to administer 0.2 to 0.5 mg per kg of weight. In intra-articular applications the doses will depend on the desired effect and the capacity of the articulation to be treated.

Contraindications

It must not be used in viral, fungal and bacterial infections which are not specifically treated, because it favours the spreading of the same throughout the organism. Do not use when gastric ulcers are suspected because they increase harmful activity by increasing the hydrochloric and peptic secretions.

Warning

Keep the product in a clean, dry place between 4º and 30ºC and out of children's reach.
Veterinary use.

Presentation

Ampoule containing 100 ml.

Formula

• Dexamethsone 21 Phosphate 25 mg
• Dexamethsone Acetate 25 mg
• Formula Agents c.s.p. 10 ml

Ketoprofen is non-steroid anti-inflammatory, anti-pyretic and analgesic and belongs chemically to Class 2 arylpropionics from the group of carboxylic acids. It is an inhibitor of cyclo-oxygenase and then inhibits the synthesis of prostaglandins, reducing the liberation of enzymes and inhibiting the migration of inflammatory cells as neutrophils and macrophages monocytes. It is metabolized at liver level and excreted mainly by renal via.

Instructions for Use

It is specially indicated for treatment of acute and chronic inflammatory processes, as well as for the elimination of painful response in muscular-skeleton disorders.

Via of Administration and Dosage

Administer by IM and EV parenteral (intravenous) via because its oral bioavailability is extremely low. By parenteral via it has a rapid and complete absorption. It combines with plasma proteins in a percentage greater than 92% and due to this fact, its distribution is low. However, it reaches high concentrations in places of inflammation. IM daily dose is 2.2 mg/Kg and it is indicated not to administer it for more than 14 days.

Contraindications

Its use is contraindicated in equines with renal disease, blood coagulating disorders, gastric ulcers and liver disease. It affects the integrity of gastric mucosa and decreases platelet aggregation interacting with anticoagulants and other NSAIDs and microsomal enzymes inducers (barbiturates)

Warning

Keep the product in a clean, dry place between 5 and 35 °C and out of children’s reach.
Veterinary use.

Presentation

Ampoule containing 100 ml of sterile injectable solution

Formula

• Ketoprofen10 g
• Formula Agents c.s.p. 100 ml

An anti-inflammatory, analgesic, anti-arthritic to be used exclusively with horses used for sport.
Fenilbutazona is a non-steroid anti-flammatory (AINE) which provides excellent absorption at gastro-intestinal level. It inhibits the arachidonic acid cascade, lowering inflammation, oedema, erythema and pain. When given on an empty stomach, the maximum concentration is achieved in the blood quicker than if it is given together with food (hay and/or grains). It is eliminated along with the bile after its transformation at hepatic level. Only 2% is eliminated in the urine.

Instructions for use

A non- steroid analgesic, anti-arthritic and anti-inflammatory for the treatment of disorders in the muscular-skeletal apparatus Arthritis, Osteo-arthritis, Arthrosis, Myositis, Myalglias, Rhabdomyolysis, Laminitis, Periarticular inflammation, Tendonitis, Tenosynovitis, Capsulitis, Bursitis, Post surgery pain, Pedal Osteitis, Bursitis of the cunean tendon, Dislocations, Navicular ailments, Sprains, Osteoarthritic ailments.

Via of Administration and Dosage

Dosage: 4,4 mg per kilo live weight This is equivalent to 2.2mg of Fenilbutazona in an animal of 500 kilos live weight or 0.44 gm of Fenilbutazona for every 100 kilos live weight An animal of 500 kilos live weight should receive 11.28 gm of the oral paste.
Frequency of dosage: Every 12 or 24 hours for the duration of the treatment.
Vía de aplicación: Oral
Treatment duración: For 3 to 5 days. This is left to the criteria of the veterinary doctor in attendance and according to how the animals respond.

Contraindications

Not to be combined with treatments with Warfarin, sulphonamides, nephrotoxic drugs (aminoglycoside antibiotics etc.)
Do not use if it is suspected that there are ulcers of the digestive tract, coagulation defects, cardiac, renal or hepatic dysfunction or when there are thyroid conditions or allergy to the drug.

Warnings

- Do not exceed the indicated dosage
- Keep out of the reach of children
- It can cause hypersensitivity in prone individuals.
- Use with caution with ponies, foals and old animals or those with renal, hepatic or hypovolemic ailments.
- Discontinue use if ulcers appear in buccal, gastric o intestinal mucous or if the stools appear black and tarry.
- Do not administer together with the ration of food as this delays absorption.
- In the case of accidental ingestion go to the doctor together with the label of the product.
- Do not administer to horses which are destined for human consumption
- In Argentina: Centro Nacional de Intoxicaciones (National Centre for Intoxications): O800-33-0160
Uso veterinario.

Presentación

Syringe of 34g

Formula

• Fenilbutazona19.5 g
• Formula Agents c.s.p. 100 g