It is a betalactamine bactericide antibiotic, which the same as all of this group, inhibit the formation of the bacterial wall and are bactericide while they are being formed.
They generate a weak wall which cannot support the pressure during the cell division stage and so break up causing bacteriolysis. For this reason, this Penicillin is more effective during the stage of logarithmical growth of the bacterial colony. It is excellent against Gram-positive germs, but not against Gram-negative bacteria producers of betalactamase (they have a wall 50 times thicker and betalactamase in the periplasmic space). It can be used individually or combined with other antibiotics such as Gentamicin.
As a conclusion, it is important to realize that rather than high doses of the antibiotic at long intervals, it is convenient to rely on a concentration of the antibiotic in stable form and for a prolonged time for optimum action.

Instructions for Use

It is indicated for animals which are immuno-supressed and immunologically immature (neonate) due to its wide safety margin as well as in septicemias, peritonitis, pneumonic processes, abscesses, musculo-skeleton infections, metritis, tetanus, clostridiosis, actinobacilosis, and actinomycosis. In pneumonia caused by Rhodococcus Equi it is convenient to associate it with Equigenta-Vet, where excellent results are observed. Also, as it is eliminated by renal excretion it is found in high concentrations in urinary tracts making it the proper chosen antibiotic for infections that affect this system.
It is not the chosen drug for meningitis due to the low concentration of the drug in cerebrospinal fluid. On the other hand, it is an innocuous antibiotic for pregnant mares. The application of 1 to 3 days of Penicillin for animals at risk of getting equine adenitis is specially recommended.

Via of Administration and Dosage

Both in young colts and adult equines it is recommended the usage by endovenous via or intramuscular via at a rate of 20000 to 50000 UI/Kg every 6-8 hours.

Contraindications

It is important to take into account that prolonged usage can produce immuno-suppression.

Warning

Keep the product in a clean, dry place between 4º and 30ºC and out of children's reach. Veterinary use

Presentation

Ampoule containing sterile lyophilized + solvent.

Formula

• Sodic Penicillin G 30.000.000 UI
• Sterile apirogen bi-distilled water 100 ml

Gentamicine is a bactericide antibiotic of aminoglycosides family and acts in an excellent way on aerobic Gram-negative bacteria. It does not act on anaerobic micro-organisms, which implies that it is a synergic antibiotic of the batelactamines since these act in excellent way on Gram-positive bacteria.
This antibiotic affects the protein synthesis of the bacteria when joined to the subunit 30 S of bacterial ribosomal.
The lethal effect on bacterial cells seems to be related to the formation of abnormal canals in the cellular membranes.
It is an antibiotic which does not get into the central nervous system or into the vitreous humor. On the other hand as it does not get through to the cellular membranes this has little effect on microorganisms which reproduces intercellularly.
It is more active at alkaline pH, so that it is not indicated for urinary infections where pH can decrease to 5.5 %. For the same reason, it is neither effective in purulent processes such as abscesses.

Instructions for Use

It is excellent for polyarthritis and septicemias in young colts, septic arthritis, uterine and urinary infections, bacterial keratitis, pneumonia produced by Rhodococcus Equi and peritonitis. In addition it fights infections produced by Escherichia Coli, P.Aeruginosa and K Pneumoniae very well, but not so the Meningitis variety.
In respiratory infections it can be administered in aerosol form.

Via of Administration and Dosage

Dosis:
In young colts use 3.3 mg/kg every 12 hours.
In adult equines administer 2-4 mg/kg by endovenous via every 8-12 hours.
In septic arthritis give by intra-articular via (50 mg/ml) and in systemic via 3.3 mg/kg every 12 hours.
In uterine infections apply 10 mg/ml in 250 ml of tepid physiological solution by intra-uterus via every day.

Contraindications

It is potentially nephrotoxic when it is used in long treatments (more than 7 days). The application previous to the service season or at the moment of it, influences fertility by affecting conception.

Warning

Do not administer by endovenous via rapidly. Keep the product in a clean, dry place between 4º and 30 ºC and out of children's reach.
Veterinary use.

Presentation

Ampoule containing 100 ml and 250 ml of sterile injectable solution.

Formula

• Gentamicine, Sulphate (base)8 g
• Formula Agents c.s.p. 100 ml

Although it is recommended to implement antibacterial therapy only after doing an anti-biogram, the therapeutical need may necessarily give rise in many cases to empirical use. In this way, Ampicillin, being an antibiotic which acts very well on gram-negative micro-organism, and also very well on gram-positive bacteria makes it a very suitable antibiotic for this kind of situation.
Ampicillin is a betalactamic antibiotic which belongs to aminopenicillin group that goes through the external layer of gram-negative bacteria. As already mentioned, its range of action not only includes gram-positive, but it is also effective with Escherichia Coli and some species of Salmonella type when it is administrated in high doses.
Although aminopenicillins can be administrated orally due to the fact that they are stable in the acid medium of stomach, ampicillin generally produces diarrhoea because it does not have a high absorption rate, so that we prefer the parental (intravenous) presentation. It has a bioavailability of about 100%.

Indications for Use

It is the chosen antibiotic for acute septicemias and endotoxic shock as well as the chosen drug together with Penicillin for urinary infections. It is also recommended for mixed cavity and organic infections as for infections of genitourinary and musculo-skeletal and respiratory systems. Ampicillin provides an excellent action in subjunctival way on infectious conjunctivitis.

Via of Administration and Dosage

In adult equines the recommended dose is between 10 and 20 mg/kg every 6 – 8 hours by endovenous or intramuscular via.
In young colts the recommended dos is between 11 to 22 mg/kg with same frequency as for adult animals.

Contraindications

There are no contraindications due to the wide margin of safety of this drug.
Do not administer together with saline solutions of dextrose because it loose its action.

Warning

Keep the product in a clean, dry place between 4º and 30ºC and out of children's reach.
Veterinary use.

Presentation

Ampoule containing sterile lyophilized + solvent

Formula

• Sodic Ampicillin5 g
• Sterile apirogen bi-distilled water 25 ml

Ampicillin is a betalactamic antibiotic which belongs to aminopenicillin group and they act very well on gram-negative microorganisms and quite well on gram-positive bacteria.
The combination of sodic and benzathine forms grants the possibility of obtaining a quick action (sodic form) and maintaining it during a longer period (benzathine form) by increasing in this way the interval between doses and so increasing the usefulness of the treatment

Indications for Use

Ampicillin being an antibiotic which acts very well on gram-negative micro-organisms and also quite well on Gram-positive bacteria, is a drug which can be used as the chosen antibiotic for acute septicemias and endotoxic shock, as well as the chosen drug together with Penicillin in urinary infections.
It is also recommended in mixed cavity and organic infections; and infections of genito-urinary and musculo-skeletal (septic arthritis) and respiratory systems. Besides it is important to emphasize its excellent action on clostridiosis. It is effective on Escherichia Coli and some species of Salmonella type when it is given in high doses.

Via of Administration and Dosage

In adult equines the recommended dose is between 10 and 20 mg/kg every 12 hours by endovenous via. In young colts the recommended dose is 11 to 22 mg/kg with the same frequency as that for adult animals by endovenous via. In intrauterine infusions it is recommended a dose of 3 g total dissolved in 250 ml of physiological solution.

Contraindications

Do not administer together with dextrose saline solutions because it looses its effect. Otherwise it has no contraindications due to the fact that it is a drug of very low toxicity.

Warning

Keep the product in a clean, dry place between 4º C and 30ºC.and out of children's reach.
Veterinary use

Presentation

Ampoule containing sterile lyophilized + solvent.

Formula

• Sodio Ampicillin2,5 g
• Benzatinic Ampicillin2,5 g
• Sterile apirogen bi-distilled water 25 ml